When the disease becomes severe one of the mechanisms is the inflammatory storm in the lungs that is created by the release of inflammatory cytokines, especially interleukin 6. Another damage by the virus is the loss of iron from hemoglobin which causes hypoxia (low blood oxygen). Blood oxygen gets really low and this is the cause of death. Loss of heme iron is similar to malaria and that’s why antimalarial drugs are being trialed.
That’s really the point of right to try. If you’re in a situation where you have a choice to try a drug that may save your life, why not try it. It’s a choice. If it’s okay to choose abortion, why isn’t it okay to try a drug that may work in this situation? If a doctor says you’re going to die, you’re going to try it unless there is some underlying reason not to try, especially if there’s a good track record for the drug and it’s been in use for years. I hope and pray the drugs being discussed and are being tried will help save lives.
What I understand is the drug (hydroxychloroquine) is approved for lupus and rheumatoid arthritis, and there is a shortage of this drug for these patients whose life depend on this drug. But for covid patients it’s not clear yet, it maybe useful or maybe not. It just takes time to get results from many clinical trials. It can be not effective at all or the dose can be very different. There are around 400 trials recruiting for different stages of the disease. Hopefully they get the results ASAP.