I'm guessing that after she reconnects with the people in Port Chuckles that are significant to her and to creating new storylines, she'll have another psychotic break and go back in a catatonic state. Luke will force himself to move on permanently with Tracy or whomever. It will be heartbreaking, to be sure.
That way, if Genie ever wants to come back, or if the powers that be ever sweeten the pot enough to bring her back, she certainly can.
They can never permanently kill off Laura, until, God forbid, Genie Francis dies.